Premium
Can fructose influence the development of obesity mediated through hypothalamic alterations?
Author(s) -
CargninCarvalho Anderson,
Mello Aline Haas,
Bressan Joice Benedet,
Backes Kassiane Mathiola,
Uberti Marcela Fornari,
Fogaça Jéssica Benedet,
Rosa Turatti Cristini,
Cavalheiro Eulla Keimili Fernandes Ferreira,
Vilela Thais Ceresér,
Rezin Gislaine Tezza
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24628
Subject(s) - fructose , context (archaeology) , animal studies , adipose tissue , obesity , endocrinology , medicine , hypothalamus , appetite , biology , food science , paleontology
Epidemiological data from the last decades point to an exponential growth in the number of obese people. Different behavioral factors, mainly associated with food consumption, appear to contribute significantly to its development. Concomitant with increased obesity rates, an increase in the consumption of fructose has been observed; therefore, fructose consumption has been implicated as an important obesogenic factor. However, changes in brain activity due to fructose consumption are possible, especially in relation to hypothalamic satiety mechanisms. In addition, the obese state may provide an environment of chronic inflammation and further contribute to the discontinuation of satiety mechanisms in the hypothalamus. We briefly review the intrinsic alterations to the increased adipose tissue, its connections with the hypothalamus in the control of energy signaling mechanisms and, consequently, the participation of fructose as a co‐adjuvant or trigger. Presenting the current context with clinical trials involving human and animal studies, we seek to contribute to a better understanding of the role of fructose in the progression of obesity.