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The emerging roles of circular RNAs in CNS injuries
Author(s) -
Qu Xiaolin,
Li Zhenxing,
Chen Jigang,
Hou Lijun
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24591
Subject(s) - circular rna , microrna , biology , central nervous system , rna , neuroscience , computational biology , transcription factor , bioinformatics , gene , genetics
With high morbidity and mortality worldwide, injuries to the central nervous system (CNS) usually result in devastating consequences. However, the underlying mechanisms have not been fully understood and current therapies are still limited. Circular RNA (circRNA) is a novel type of endogenous noncoding RNAs, characterized by covalently closed annular structure. It is gradually recognized that circRNAs are involved in multiple biological processes, such as acting as microRNA sponges or scaffolds during the assembly of protein complex and modulating the transcription of certain genes. Interestingly, circRNAs have been found to be highly expressed in the CNS, which indicates their neurospecificity. Several circRNAs have already been discovered to be associated with multiple pathophysiological processes following neurological diseases. Currently, the molecular roles of circRNAs in CNS injuries have gained increasing attention, leading to uninterrupted relevant researches. Herein, we presented a review of current studies on the role of circRNAs in CNS injuries. The therapeutic potency of circRNAs in CNS injuries was also analyzed.