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PPARα serves as a new receptor of aspirin for neuroprotection
Author(s) -
Patel Dhruv,
Roy Avik,
Pahan Kalipada
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24561
Subject(s) - neuroprotection , aspirin , peroxisome proliferator activated receptor , receptor , downregulation and upregulation , pharmacology , hippocampal formation , neurotrophic factors , neuroscience , stimulation , medicine , chemistry , biology , biochemistry , gene
Acetyl salicylic acid, commonly known as aspirin, has been being widely used as an anti‐inflammatory drug for almost 100 years. However, there was no receptor known for this popular drug. Recently, we have established that peroxisome proliferator‐activated receptor alpha (PPARα) acts as a novel receptor of aspirin. Activation of PPARα by aspirin stimulated a series of downstream signaling pathways that could potentially ameliorate different Alzheimer's disease (AD)‐related pathologies. In this mini‐review, we have discussed how aspirin–PPARα interaction plays a pivotal role in the amelioration of AD pathology via the stimulation of neurotrophic factors, upregulation of plasticity‐associated genes, and removal of plaque burden in hippocampal neurons.