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Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes
Author(s) -
Guo Ling Yi,
Lozinski Brian,
Yong Voon Wee
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24524
Subject(s) - remyelination , astrogliosis , multiple sclerosis , central nervous system , neurodegeneration , neuroprotection , neuroscience , medicine , neuroinflammation , disease , spinal cord injury , experimental autoimmune encephalomyelitis , spinal cord , immunology , psychology , myelin , pathology
Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by inflammation, demyelination, and neurodegeneration. Emerging research suggests that exercise has therapeutic benefits for MS patients but the clinical data have focused primarily on non‐CNS outcomes. In this review, we discuss evidence in preclinical MS models that exercise influences oligodendrocyte proliferation and repopulation, remyelination, neuroinflammation, neuroprotection, axonal regeneration, and astrogliosis. Evidence for the therapeutic effects of exercise in MS is further supplemented by data from other CNS diseases, including Alzheimer's disease, Parkinson's disease, and spinal cord injury. These results motivate studies into the benefits that exercise confers within the CNS in MS.