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Higher serum VGF protein levels discriminate bipolar depression from major depressive disorder
Author(s) -
Chen Suzhen,
Jiang Haitang,
Hou Zhenhua,
Yue Yingying,
Zhang Yuqun,
Zhao Fuying,
Xu Zhi,
Li Yinghui,
Mou Xiaodong,
Li Lei,
Wang Tianyu,
Zhao Jingjing,
Han Chongyang,
Sui Yuxiu,
Wang Ming,
Yang Zhong,
Lu Yan,
Zhu Yifeng,
Li Jianhua,
Shen Xinhua,
Sun Fei,
Chen Qingsong,
Yuan Yonggui
Publication year - 2019
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24377
Subject(s) - major depressive disorder , medicine , bipolar disorder , depression (economics) , receiver operating characteristic , correlation , gastroenterology , endocrinology , geometry , mathematics , amygdala , lithium (medication) , economics , macroeconomics
Misdiagnosis between major depressive disorder (MDD) and bipolar depression (BD) is quite common. Our previous study found significantly lower serum VGF (non‐acronymic) in MDD patients. However, it is unclear whether same changes occur in BD patients. Therefore, we aimed to investigate the relationship between serum VGF levels in BD and MDD patients. General information, scores of 17‐item Hamilton Depression Rating Scale (HDRS), and fasting blood samples of all participants including 30 MDD patients, 20 BD patients, and 30 healthy controls (HC) were collected. Serum VGF levels were measured by Enzyme‐linked immunosorbent assay kits. Pearson correlation analysis was used to analyze correlations between serum VGF levels and clinical information. Receiver operating characteristic (ROC) curve and likelihood ratios (LRs) were used to analyze the differential potential of serum VGF. Serum VGF levels were significantly lower in MDD patients but higher in BD patients compared with HC (both P Tukey < 0.01). No correlation was found between serum VGF levels and any data of subjects. The optimal cutoff for serum VGF in discriminating BD patients from MDD patients was ≥1093.85 pg/ml (AUC = 0.990, sensitivity of 95%, specificity of 100% and accuracy of 95%). LRs further confirmed the differential efficiency of serum VGF in distinguishing BD and MDD patients with +LR of infinity and –LR of 0. The results suggest that serum VGF level changed significantly in MDD and BD patients and serum VGF may be an indicator for differentiating BD patients from MDD patients.