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Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
Author(s) -
Volgin Andrey D.,
Yakovlev Oleg A.,
Demin Konstantin A.,
de Abreu Murilo S.,
Alekseeva Polina A.,
Friend Ashton J.,
Lakstygal Anton M.,
Amstislavskaya Tamara G.,
Bao Wandong,
Song Cai,
Kalueff Allan V.
Publication year - 2019
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24337
Subject(s) - zebrafish , danio , biomedicine , model organism , biology , computational biology , disease , genome , personalized medicine , genetics , bioinformatics , gene , medicine , pathology
Abstract Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish ( Danio rerio ) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient‐centered personalized psychiatry.