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Insights into major facilitator superfamily domain‐containing protein‐2a (Mfsd2a) in physiology and pathophysiology. What do we know so far?
Author(s) -
Eser Ocak Pinar,
Ocak Umut,
Sherchan Prativa,
Zhang John H.,
Tang Jiping
Publication year - 2020
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24327
Subject(s) - major facilitator superfamily , neuroscience , facilitator , function (biology) , biology , transporter , neuroinflammation , blood–brain barrier , inflammation , microbiology and biotechnology , central nervous system , psychology , immunology , genetics , gene , social psychology
Major facilitator superfamily domain‐containing protein‐2a (Mfsd2a) which was considered as an orphan transporter has recently gained attention for its regulatory role in the maintenance of proper functioning of the blood–brain barrier. Besides the major role of Mfsd2a in maintaining the barrier function, increasing evidence has emerged with regard to the contributions of Mfsd2a to various biological processes such as transport, cell fusion, cell cycle, inflammation and regeneration, managing tumor growth, functioning of other organs with barrier functions or responses to injury. The purpose of this article is to review the different roles of Mfsd2a and its involvement in the physiological and pathophysiological processes primarily in the central nervous system and throughout the mammalian body under the lights of the current literature.