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Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities
Author(s) -
Calabrese Vittorio,
Santoro Aurelia,
Trovato Salinaro Angela,
Modafferi Sergio,
Scuto Maria,
Albouchi Ferdaous,
Monti Daniela,
Giordano James,
Zappia Mario,
Franceschi Claudio,
Calabrese Edward J
Publication year - 2018
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24244
Subject(s) - hormesis , disease , neuroscience , parkinson's disease , psychology , cognitive science , medicine , intensive care medicine , oxidative stress
Age‐related changes in the brain reflect a dynamic interaction of genetic, epigenetic, phenotypic, and environmental factors that can be temporally restricted or more longitudinally present throughout the lifespan. Fundamental to these mechanisms is the capacity for physiological adaptation through modulation of diverse molecular and biochemical signaling occurring from the intracellular to the network‐systemic level throughout the brain. A number of agents that affect the onset and progression of Parkinson's disease (PD)‐like effects in experimental models exhibit temporal features, and mechanisms of hormetic dose responses. These findings have particular significance since the hormetic dose response describes the amplitude and range of potential therapeutic effects, thereby affecting the design and conduct of studies of interventions against PD (and other neurodegenerative diseases), and may also be important to a broader consideration of hormetic processes in resilient adaptive responses that might afford protection against the onset and/or progression of PD and related disorders.