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A novel cell‐cell communication mechanism in the nervous system: exosomes
Author(s) -
Zhang Guan,
Yang Ping
Publication year - 2018
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24113
Subject(s) - microvesicles , intracellular , exosome , nervous system , biology , microbiology and biotechnology , extracellular , neuroscience , secretion , mechanism (biology) , cell , synapse , microrna , biochemistry , philosophy , epistemology , gene
Abstract Exosomes are small extracellular membrane‐based vesicles with a variety of cargoes that are involved in numerous physiological and pathological processes in the nervous system. Accumulating evidence has implicated that exosomes are emerging as a novel form of intercellular communication within the nervous system. In this review, we first illustrate exosome metabolism including its formation, secretion, transport, and uptake. Second, we compare exosomes to synaptic vesicles in terms of intercellular messengers and communicators. Third, we discuss the roles and prospects of exosomes in the diagnosis and treatment of neurodegenerative diseases.