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Improved prediction of direction‐dependent, acute axonal injury in piglets
Author(s) -
Atlan Lorre S.,
Smith Colin,
Margulies Susan S.
Publication year - 2018
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24108
Subject(s) - diffuse axonal injury , kinematics , traumatic brain injury , white matter , coronal plane , head injury , sagittal plane , physical medicine and rehabilitation , medicine , head (geology) , poison control , anatomy , surgery , magnetic resonance imaging , physics , biology , radiology , emergency medicine , paleontology , classical mechanics , psychiatry
To guide development of safety equipment that reduces sports‐related head injuries, we sought to enhance predictive relationships between head movement and acute axonal injury severity. The severity of traumatic brain injury (TBI) is influenced by the magnitude and direction of head kinematics. Previous studies have demonstrated correlation between rotational head kinematics and symptom severity in the adult. More recent studies have demonstrated brain injury age‐ and direction‐dependence, relating head kinematics to white matter tract‐oriented strains. We have recently developed and assessed novel rotational head kinematic parameters as predictors of white matter damage in the female immature piglet. We show that many previously published rotational kinematic injury predictor metrics poorly predict acute axonal pathology induced by rapid, non‐impact head rotations and that inclusion of cerebral moments of inertia (MOI) in rotational head injury metrics refines prediction of diffuse axonal injury following rapid head rotations for two immature age groups. Rotational Work (RotWork) was the best significant predictor of traumatic axonal injury in both newborn and pre‐adolescent piglets following head rotations in the axial, coronal, and sagittal planes. An improvement over current metrics, we find that RotWork, which incorporates head rotation rate, direction, and brain shape, significantly enhanced acute traumatic axonal injury prediction. For similar injury extent, the RotWork threshold is lower for the newborn piglet than the pre‐adolescent.