Premium
Roles of AEG‐1 in CNS neurons and astrocytes during noncancerous processes
Author(s) -
Yin Xiang,
Feng Honglin
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24044
Subject(s) - excitotoxicity , astrocyte , biology , neuroscience , endoplasmic reticulum , glutamate receptor , pi3k/akt/mtor pathway , signal transduction , central nervous system , microbiology and biotechnology , genetics , receptor
Since its initial identification, Astrocyte Elevated Gene‐1 ( AEG‐1 ) has been recognized as a “star” gene detected in most of the analyzed cancers; AEG‐1 can interact with signaling transduction molecules, such as PI3K/Akt and MAPK, to affect the function and viability of cells. Furthermore, its multiple other functions are also gradually being recognized. AEG‐1 participates in several biological processes, including embryonic development, glutamate excitotoxicity, inflammation, and endoplasmic reticulum stress. Most of the noncancerous roles of the AEG‐1 were identified in studies of the neurological disorders of the CNS. As an oncogene that promotes aberrant cellular processes within the CNS, AEG‐1 may also represent an important therapeutic target for the treatment of neurological disease. However, the exact role of the AEG‐1 in CNS under normal conditions is still unknown. This review will focus on the literature describing the role of this molecule in CNS neurons and astrocytes during noncancerous processes. © 2017 Wiley Periodicals, Inc.