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Transplantation with hypoxia‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats
Author(s) -
Wang Jiwen,
Qiu Yuru,
Fu Yue,
Liu Jun,
He ZhiJie,
Huang Zitong
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24025
Subject(s) - mesenchymal stem cell , hypoxia (environmental) , medicine , transplantation , ischemia , cerebral hypoxia , cardiology , pathology , chemistry , organic chemistry , oxygen
Cardiac arrest–induced global cerebral ischemia is a main cause of neurological dysfunction in emergency medicine. Transplantation with bone marrow mesenchymal stem cells (MSCs) has been used in stroke models to repair the ischemic brain injury, but it is little studied in models with global cerebral ischemia. In the present study, a hypoxia precondition was used to improve the efficacy of MSC transplantation, given the low survival and migration rates and limited differentiation capacities of MSCs. We found that hypoxia can increase the expansion and migration of MSCs by activating the PI3K/AKT and hypoxia‐inducible factor‐1α/CXC chemokine receptor‐4 pathways. By using a cardiac arrest–induced global cerebral ischemic model in rats, we found that transplantation of hypoxia‐preconditioned MSCs promoted the migration and integration of MSCs and decreased neuronal death and inflammation in the ischemic cortex. © 2017 Wiley Periodicals, Inc.