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Netrin‐1 overexpression improves neurobehavioral outcomes and reduces infarct size via inhibition of the notch1 pathway following experimental stroke
Author(s) -
Yang Xiaosheng,
Li Shiting,
Li Bin,
Wang Xiaoqiang,
Sun Chongran,
Qin Haiqiang,
Sun Hui
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24018
Subject(s) - netrin , stroke (engine) , medicine , gerbil , blot , immunocytochemistry , pharmacology , neuroscience , psychology , ischemia , biology , gene , receptor , axon guidance , mechanical engineering , biochemistry , engineering
Stroke is a leading cause of morbidity and mortality worldwide. Administration of Netrin‐1 during the peri‐infarct period has been shown to decrease infarct size in rats; however, the underlying mechanism is unclear. We addressed this question in the present study by inducing stroke in rats via middle cerebral artery occlusion (MCAO), and evaluating the effects of Netrin‐1 treatment by neurobehavioral testing, immunocytochemistry, and western blotting. Netrin‐1 overexpression increased neurobehavioral test scores and reduced cerebral infarct volume following MCAO via inhibition of the Notch1 signaling pathway. These results demonstrate that early administration of Netrin‐1 can is an effective therapeutic approach for improving outcome after stroke. © 2017 Wiley Periodicals, Inc.