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The function of NOD‐like receptors in central nervous system diseases
Author(s) -
Kong Xiangxi,
Yuan Zengqiang,
Cheng Jinbo
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.24004
Subject(s) - multiple sclerosis , receptor , immune system , disease , neuroscience , biology , immunology , innate immune system , central nervous system , nod , pattern recognition receptor , medicine , diabetes mellitus , genetics , pathology , endocrinology
NOD‐like receptors (NLRs) are critical cytoplasmic pattern‐recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and autoimmune disorders. Recent studies have indicated that the proteins of the NLR family are linked with the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), and psychological diseases. In this review, we mainly focus on the role of NLRs and the underlying signaling pathways in central nervous system (CNS) diseases. © 2016 Wiley Periodicals, Inc.