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Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state
Author(s) -
Calabrese Vittorio,
Giordano James,
Crupi Rosalia,
Di Paola Rosanna,
Ruggieri Martino,
Bianchini Rio,
Ontario Maria Laura,
Cuzzocrea Salvatore,
Calabrese Edward J.
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23967
Subject(s) - neuroinflammation , hormesis , oxidative stress , neuroprotection , schizophrenia (object oriented programming) , neuroscience , cellular stress response , heme oxygenase , biology , bioinformatics , medicine , heme , immunology , psychiatry , inflammation , fight or flight response , endocrinology , genetics , biochemistry , gene , enzyme
Abnormal redox homeostasis and oxidative stress have been proposed to play a role in the etiology of several neuropsychiatric spectrum disorders. Emerging interest has recently focused on markers of oxidative stress and neuroinflammation in schizophrenic spectrum disorders, at least in particular subgroups of patients. Altered expression of genes related to oxidative stress, oxidative damage to DNA, protein and lipids, as well as reduced glutathione levels in central and peripheral tissues could act synergistically, and contribute to the course of the disease. Herein, we discuss cellular mechanisms that may be operative in neuroinflammation and contributory to schizophrenia. We address modulation of endogenous cellular defense mechanisms as a potentially innovative approach to therapeutics for schizophrenia, and other neuropsychiatric conditions that are associated with neuroinflammation. Specifically, we discuss the emerging role of heme oxygenase as prominent member of neuroprotective network in redox stress responsive mechanisms, as well as the importance of glutathione relevant in schizophrenia pathophysiology. Finally we introduce the hormetic dose response concept as relevant and important to neuroprotection, and review hormetic mechanisms as possible approaches to manipulation of neuroinflammatory targets that may be viable for treating schizophrenia spectrum disorders. © 2016 Wiley Periodicals, Inc.