Premium
Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for A lzheimer's Disease
Author(s) -
Habib Ahsan,
Sawmiller Darrell,
Tan Jun
Publication year - 2017
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23823
Subject(s) - neuroprotection , amyloid precursor protein , neurogenesis , proteolysis , neuroscience , amyloid precursor protein secretase , microbiology and biotechnology , amyloid (mycology) , synaptic plasticity , effector , alzheimer's disease , biology , receptor , chemistry , disease , medicine , biochemistry , pathology , botany , enzyme
Soluble amyloid precursor protein α (sAPPα), a secreted proteolytic fragment of nonamyloidogenic amyloid precursor protein (APP) processing, is known for numerous neuroprotective functions. These functions include but are not limited to proliferation, neuroprotection, synaptic plasticity, memory formation, neurogenesis, and neuritogenesis in cell culture and animal models. In addition, sAPPα influences amyloid‐β (Aβ) production by direct modulation of APP β‐secretase proteolysis as well as Aβ‐related or unrelated tau pathology, hallmark pathologies of Alzheimer's disease (AD). Thus, the restoration of sAPPα levels and functions in the brain by increasing nonamyloidogenic APP processing and/or manipulation of its signaling could reduce AD pathology and cognitive impairment. It is likely that identification and characterization of sAPPα receptors in the brain, downstream effectors, and signaling pathways will pave the way for an attractive therapeutic target for AD prevention or intervention. © 2016 Wiley Periodicals, Inc.