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Permissive role of cytosolic pH acidification in neurodegeneration: A closer look at its causes and consequences
Author(s) -
Majdi Alireza,
Mahmoudi Javad,
SadighEteghad Saeed,
Golzari Samad E.J.,
Sabermarouf Babak,
ReyhaniRad Siamak
Publication year - 2016
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23757
Subject(s) - neurodegeneration , cytosol , excitotoxicity , oxidative stress , microbiology and biotechnology , chemistry , neuroscience , biochemistry , biology , apoptosis , programmed cell death , medicine , enzyme , disease , pathology
The maintenance of cytosolic pH in its physiological range is required for normal neuronal activity, and even minor alterations can have serious consequences. This Review summarizes the current understanding of the conditions that are associated with cytosolic pH disruption and that lead to abnormal cytosolic acidification. Oxidative stress results in cytosolic acidification, and this plays a crucial role in the emergence of apoptosis in protein misfolding and excitotoxicity, ultimately leading to irreversible neuronal damage. Through the identification of mechanisms by which intraneuronal pH acidification promotes neurodegeneration, we may identify new approaches for preventing and treating neurodegenerative disorders. © 2016 Wiley Periodicals, Inc.