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Keratan sulfate exacerbates experimental autoimmune encephalomyelitis
Author(s) -
Ueno Rino,
Miyamoto Katsuichi,
Tanaka Noriko,
Moriguchi Kota,
Kadomatsu Kenji,
Kusunoki Susumu
Publication year - 2015
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23640
Subject(s) - experimental autoimmune encephalomyelitis , encephalomyelitis , immune system , keratan sulfate , central nervous system , immunology , glycosaminoglycan , chemistry , heparan sulfate , biology , microbiology and biotechnology , multiple sclerosis , neuroscience , biochemistry , chondroitin sulfate
Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis (EAE) in mice that were deficient in the N‐acetylglucosamine (GlcNAc)‐6‐O‐sulfotransferase 1 (GlcNAc6ST1) gene (KS‐KO). KS‐KO mice developed less severe EAE and showed repressed recall response in the induction phase. Furthermore, GlcNAc6ST1 might have roles in the passage of the pathogenic lymphocytes through the blood–brain barrier via adhesion molecules. Thus, modulation of KS may become a treatment for neuroimmunological diseases. © 2015 Wiley Periodicals, Inc.