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Glucose, lactate, and shuttling of metabolites in vertebrate retinas
Author(s) -
Hurley James B.,
Lindsay Kenneth J.,
Du Jianhai
Publication year - 2015
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23583
Subject(s) - retina , neuroscience , glycolysis , biology , anaerobic glycolysis , muller glia , vertebrate , metabolism , biophysics , microbiology and biotechnology , biochemistry , progenitor cell , stem cell , gene
The vertebrate retina has specific functions and structures that give it a unique set of constraints on the way in which it can produce and use metabolic energy. The retina's response to illumination influences its energy requirements, and the retina's laminated structure influences the extent to which neurons and glia can access metabolic fuels. There are fundamental differences between energy metabolism in retina and that in brain. The retina relies on aerobic glycolysis much more than the brain does, and morphological differences between retina and brain limit the types of metabolic relationships that are possible between neurons and glia. This Mini‐Review summarizes the unique metabolic features of the retina with a focus on the role of lactate shuttling. © 2015 Wiley Periodicals, Inc.