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Motor activity in young APP swe + PS1 /A246E bigenic mice as a predicting variable for memory decline
Author(s) -
Filali Mohammed,
Lalonde Robert
Publication year - 2015
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23552
Subject(s) - neuropathology , open field , neuroscience , cognition , psychology , medicine , recognition memory , physiology , developmental psychology , disease
Reports of individuality in rodent species have been a subject of debate in pharmacology and other fields. In the current study, APP swe + PS1 /A246E bigenic mice with Alzheimer's‐like pathogenesis and wild‐type controls were subdivided at 3 months of age into low, intermediate, and high responders in open‐field activity. The mice were then evaluated longitudinally at 3 and 9 months for object recognition. Irrespective of genotype, mice with a high level of motor activity had better scores in object recognition. However, a significant correlation was established between open‐field activity measured at 3 months of age and recognition memory measured at 9 months of age in the bigenic group only. These results indicate that motor activity in young mice with amyloid neuropathology may serve as a predicting variable for cognitive dysfunction in more mature mice. © 2015 Wiley Periodicals, Inc.