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Impact of nuclear factor‐κB on restoration of neuron growth and differentiation in hippocampus of degenerative brain
Author(s) -
Aloor Rohit,
Zhang Christine,
Bandyopadhyay Mausumi,
Dasgupta Subhajit
Publication year - 2015
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23547
Subject(s) - neurogenesis , transcription factor , microbiology and biotechnology , nf κb , biology , inflammation , phosphorylation , neuroscience , cancer research , gene , signal transduction , immunology , genetics
The mode of action of nuclear factor‐κB (NF‐κB) has been extensively observed in different aspects of cell growth and proliferation. The transcription factor regulates various genes controlling inflammation and anti‐inflammatory responses in different tissues. Thus, NF‐κB signal gains a therapeutic prospect. The activation of NF‐κB requires nuclear localization of its p65 subunit. Research also indicates an impact of phosphorylated p65 on the transcription of genes during cell growth and the immune response. Following the trends in investigations over decades, different observations suggest that NF‐κB activation and phosphorylation of p65 regulate neuronal plasticity. Also, inhibition of NF‐κB activation is a well‐demonstrated way to attenuate inflammation. In addition to anti‐inflammatory drugs, recent researches unwind a way to regulate regeneration and repair tissue damage. Thus, keeping a critical view on NF‐κB signals, we propose the importance of natural or synthetic NF‐κB activators for neurogenesis. © 2015 Wiley Periodicals, Inc.