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Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer's disease
Author(s) -
Esfandiary Ebrahim,
Karimipour Mohammad,
Mardani Mohammad,
Alaei Hojjatallah,
Ghannadian Mustafa,
Kazemi Mohammad,
Mohammadnejad Daryoush,
Hosseini Nasrin,
Esmaeili Abolghasem
Publication year - 2014
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23319
Subject(s) - neurogenesis , synaptogenesis , rosa × damascena , neuroscience , hippocampus , disease , psychology , memory impairment , dementia , cognition , biology , medicine , food science , essential oil
The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. Emerging evidence suggests that loss of neurons and synapses are correlated with dementia in this devastating disease. Therefore, neurogenesis and synaptogenesis in adulthood could serve as a preventive as well as a therapeutic target for AD. This study investigated the effect of Rosa damascena extract on neurogenesis and synaptogenesis in an animal model of AD. Molecular, cellular, and behavioral experiments revealed that this treatment could induce neurogenesis and synaptic plasticity and improve memory in AD. Our study suggests that R. damascena is a promising treatment for mild memory impairments and AD. © 2013 Wiley Periodicals, Inc.