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2‐Phenylethynyl‐butyltellurium attenuates amyloid‐β peptide(25–35)‐induced learning and memory impairments in mice
Author(s) -
Souza Ana Cristina Guerra,
Sari Marcel Henrique Marcondes,
Pinton Simone,
Luchese Cristiane,
Neto José Sebastião Santos,
Nogueira Cristina Wayne
Publication year - 2013
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23211
Subject(s) - morris water navigation task , memory impairment , latency (audio) , water maze , inhibitory postsynaptic potential , cognitive impairment , psychology , memoria , neuroscience , pharmacology , medicine , cognition , audiology , anesthesia , hippocampus , computer science , telecommunications
Our previous study demonstrated that 2‐phenylethynyl‐butyltellurium (PEBT), an organotellurium compound, enhances memory in mice. In this study, the effects of PEBT on cognitive impairment induced by Aβ 25–35 were assessed by Morris water maze and step‐down inhibitory avoidance tasks. Mice received a single intracerebroventricular injection of Aβ 25–35 (3 nmol/3 μl/per site) and a daily oral administration of PEBT (1 mg/kg, for 10 days). PEBT significantly improved Aβ‐induced learning deficits on the training session in the Morris water maze. At the probe trial session, PEBT significantly decreased the escape latency and increased the number of crossings in the platform local compared with the Aβ‐treated group. PEBT significantly improved Aβ‐induced memory impairment in the step‐down inhibitory avoidance task. General locomotor activity was similar in all groups. This study showed that PEBT ameliorated the impairments of spatial and nonspatial long‐term memory evaluated on Morris water maze and step‐down inhibitory avoidance tasks, respectively. The results suggest that PEBT could be considered a candidate for the prevention of memory deficits such as those observed in Alzheimer's disease. © 2013 Wiley Periodicals, Inc.