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Activity‐dependent energy budget for neocortical signaling: Effect of short‐term synaptic plasticity on the energy expended by spiking and synaptic activity
Author(s) -
DiNuzzo Mauro,
Giove Federico
Publication year - 2012
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23098
Subject(s) - synaptic plasticity , neocortex , neuroscience , nonsynaptic plasticity , synaptic fatigue , synaptic augmentation , synaptic scaling , plasticity , biology , metaplasticity , excitatory postsynaptic potential , physics , inhibitory postsynaptic potential , receptor , biochemistry , thermodynamics
The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short‐term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity. © 2012 Wiley Periodicals, Inc.