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Radiation‐induced early changes in the brain and behavior: Serial diffusion tensor imaging and behavioral evaluation after graded doses of radiation
Author(s) -
Trivedi Richa,
Khan Ahmad Raza,
Rana Poonam,
Haridas Seenu,
Hemanth Kumar B.S.,
Manda Kailash,
Rathore Ram K.S.,
Tripathi Rajendra P.,
Khushu Subash
Publication year - 2012
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.23073
Subject(s) - diffusion mri , fractional anisotropy , cingulum (brain) , medicine , corpus callosum , hippocampus , nuclear medicine , cerebral peduncle , magnetic resonance imaging , internal capsule , white matter , neuroscience , pathology , psychology , radiology
The nuclear arsenal and the use of nuclear technologies have enhanced the likelihood of whole‐body/partial‐body radiation exposure. The central nervous system is highly susceptible to even low doses of radiation. With the aim of detecting and monitoring the pathologic changes of radiation‐induced damage in brain parenchyma, we used serial diffusion tensor magnetic resonance imaging (DTI) with a 7T magnetic resonance unit and neurobehavioral assessments mice irradiated with 3‐, 5‐, and 8‐Gy doses of radiation. Fractional anisotropy (FA) and mean diffusivity (MD) values at each time point (baseline, day 1, day 5, and day 10) were quantified from hippocampus, thalamus, hypothalamus, cudate‐putamen, frontal cortex, sensorimotor cortex, corpus callosum, cingulum, and cerebral peduncle. Behavioral tests were performed at baseline, day 5, and day 10. A decrease in FA values with time was observed in all three groups. At day 10, dose‐dependent decreases in FA and MD values were observed in all of the regions compared with baseline. Behavioral data obtained in this study correlate with FA values. Radiation‐induced affective disorders were not radiation dose dependent, insofar as the anxiety‐like symptoms at the lower dose (3 Gy) mimics to the symptoms with the higher dose (8 Gy) level but not with the moderate dose. However, there was a dose‐dependent decline in cognitive function as well as FA values. Behavioral data support the DTI indices, so it is suggested that DTI may be a useful tool for noninvasive monitoring of radiation‐induced brain injury. © 2012 Wiley Periodicals, Inc.