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Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction
Author(s) -
Tokunaga Shinji,
Araki Toshiyuki
Publication year - 2012
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.22792
Subject(s) - wallerian degeneration , mitochondrion , programmed cell death , microbiology and biotechnology , biology , cell , ischemia , neuroscience , apoptosis , medicine , genetics
Ischemia elicits a variety of stress responses in neuronal cells, which result in cell death. wld S Mice bear a mutation that significantly delays Wallerian degeneration. This mutation also protects all neuronal cells against other types of stresses resulting in cell death, including ischemia. To clarify the types of stresses that neuronal cell bodies derived from wld S mice are protected from, we exposed primary cultured neurons derived from wld S mice to various components of hypoxic stress. We found that wld S mouse neurons are protected against cellular injury induced by reoxygenation following hypoxic stress. Furthermore, we found that wld S mouse neurons are protected against functional impairment of the mitochondrial electron transport chain. These data suggest that Wld S protein expression may provide protection against neuronal cell death caused by mechanisms involving mitochondrial electron transport dysfunction. © 2011 Wiley Periodicals, Inc.