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Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia
Author(s) -
Barnes Michael R.,
HuxleyJones Julie,
Maycox Peter R.,
Len Mark,
Thornber Amy,
Kelly Fiona,
Bates Stewart,
Taylor Adam,
Reid Juliet,
Jones Neil,
Schroeder Jörn,
Scorer Carol A.,
Davies Ceri,
Hagan Jim J.,
Kew James N.C.,
Angelinetta Claire,
Akbar Tariq,
Hirsch Steven,
Mortimer Ann M.,
Barnes Thomas R.E.,
de Belleroche Jackie
Publication year - 2011
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.22647
Subject(s) - prefrontal cortex , schizophrenia (object oriented programming) , neuroscience , biology , neuroplasticity , psychology , cognition , psychiatry
The molecular basis of schizophrenia is poorly understood; however, different brain regions are believed to play distinct roles in disease symptomology. We have studied gene expression in the superior temporal cortex (Brodmann area 22; BA22), which may play a role in positive pathophysiology, and compared our results with data from the anterior prefrontal cortex (BA10), which shows evidence for a role in negative symptoms. Genome‐wide mRNA expression was determined in the BA22 region in 23 schizophrenics and 19 controls and compared with a BA10 data set from the same subjects. After adjustments for confounding sources of variation, we carried out GeneGO pathway enrichment analysis in each region. Significant differences were seen in age‐related transcriptional changes between the BA22 and the BA10 regions, 21.8% and 41.4% of disease‐associated transcripts showing age association, respectively. After removing age associated changes from our data, we saw the highest enrichment in processes mediating cell adhesion, synaptic contact, cytoskeletal remodelling, and apoptosis in the BA22 region. For the BA10 region, we observed the strongest changes in reproductive signalling, tissue remodelling, and cell differentiation. Further exploratory analysis also identified potentially disease‐relevant processes that were undetected in our more stringent primary analysis, including autophagy in the BA22 region and the amyloid process in the BA10 region. Collectively, our analysis suggests disruption of many common pathways and processes underpinning synaptic plasticity in both regions in schizophrenia, whereas individual regions emphasize changes in certain pathways that may help to highlight pathway‐specific therapeutic opportunities to treat negative or positive symptoms of the disease. © 2011 Wiley‐Liss, Inc.