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Peptidylgycine α‐amidating monooxygenase and copper: A gene–nutrient interaction critical to nervous system function
Author(s) -
BousquetMoore Danielle,
Mains Richard E.,
Eipper Betty A.
Publication year - 2010
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.22404
Subject(s) - monooxygenase , neuropeptide , enzyme , copper , chemistry , microbiology and biotechnology , biochemistry , nervous system , biology , neuroscience , receptor , cytochrome p450 , organic chemistry
Peptidylgycine α‐amidating monooxygenase (PAM), a highly conserved copper‐dependent enzyme, is essential for the synthesis of all amidated neuropeptides. Biophysical studies revealed that the binding of copper to PAM affects its structure, and cell biological studies demonstrated that the endocytic trafficking of PAM was sensitive to copper. We review data indicating that genetic reduction of PAM expression and mild copper deficiency in mice cause similar alterations in several physiological functions known to be regulated by neuropeptides: thermal regulation, seizure sensitivity, and anxiety‐like behavior. © 2010 Wiley‐Liss, Inc.