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DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects
Author(s) -
Perez Sylvia E.,
Berg Brian M.,
Moore Kenneth A.,
He Bin,
Counts Scott E.,
Fritz Jason J.,
Hu YuanShih,
Lazarov Orly,
Lah James J.,
Mufson Elliott J.
Publication year - 2010
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.22266
Subject(s) - docosahexaenoic acid , genetically modified mouse , endocrinology , hippocampus , medicine , arachidonic acid , transgene , biology , striatum , ratón , fatty acid , biochemistry , polyunsaturated fatty acid , dopamine , gene , enzyme
Epidemiological and clinical trial findings suggest that consumption of docosahexaenoic acid (DHA) lowers the risk of Alzhemier's disease (AD). We examined the effects of short‐term (3 months) DHA enriched diet on plaque deposition and synaptic deficts in forebrain of young APPswe/PS1ΔE9 transgenic (tg) and non‐transgenic (ntg) mice. Gas chromatography revealed a significant increase in DHA concomitant with a decrease of arachidonic acid in both brain and liver in mice fed with DHA. Female tg mice consumed relatively more food daily than ntg female mice, independent of diet. Plaque load was significantly reduced in the cortex, ventral hippocampus and striatum of female APPswe/PS1ΔE9 tg mice on DHA diet compared to female tg mice on control diet. Immunoblot quantitation of the APOE receptor, LR11, which is involved in APP trafficking and Aβ production, were unchanged in mice on DHA or control diets. Moreover drebrin levels were significantly increased in the hippocampus of tg mice on the DHA diet. Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in reducing brain insults in female AD patients. © 2009 Wiley‐Liss, Inc.