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NCAM‐induced intracellular signaling revisited
Author(s) -
Ditlevsen Dorte Kornerup,
Povlsen Gro Klitgaard,
Berezin Vladimir,
Bock Elisabeth
Publication year - 2008
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.21551
Subject(s) - neural cell adhesion molecule , fyn , microbiology and biotechnology , neurite , intracellular , kinase , signal transduction , cell adhesion molecule , chemistry , cell adhesion , biology , neuroscience , cell , proto oncogene tyrosine protein kinase src , biochemistry , in vitro
The neural cell adhesion molecule (NCAM) plays a crucial role in neuronal development, synaptic plasticity, and regeneration. NCAM works as “smart glue” that not only mediates cell–cell adhesion but also induces activation of a complex network of intracellular signaling cascades on homophilic or heterophilic binding. Stimulation of NCAM by homophilic interactions induces neuronal differentiation through activation of a number of signaling molecules, including the fibroblast growth factor receptor, non–receptor kinases Fyn and focal adhesion kinase, growth‐associated protein‐43, the mitogen‐activated protein kinase pathway, intracellular Ca 2+ , and protein kinases A, C, and G. This review presents and discusses the current knowledge in the area of NCAM signaling with a focus on the events involved in NCAM‐mediated neurite outgrowth. © 2007 Wiley‐Liss, Inc.