Premium
Genetic control of basal midbrain development
Author(s) -
Puelles Eduardo
Publication year - 2007
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.21363
Subject(s) - midbrain , hindbrain , neuroscience , biology , transcription factor , dopaminergic , basal ganglia , spinal cord , central nervous system , dopamine , genetics , gene
Recent breakthroughs in the understanding of the genetic program that controls specification of ventral cell fate in the spinal cord and hindbrain have produced useful tools for the study of similar genetic networks in the more complex rostral regions of the central nervous system. Several research groups have elucidated key factors in the potential signaling processes, as well as transcription factors necessary for differentiation of various basal midbrain nuclei. Importantly, there has been substantial progress in understanding the genetic cascade involved in specifying dopaminergic neurons. This knowledge will be crucial in the understanding and possible treatment of Parkinson's disease. © 2007 Wiley‐Liss, Inc.