Premium
Leucine‐rich repeat proteins of synapses
Author(s) -
Ko Jaewon,
Kim Eunjoon
Publication year - 2007
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.21306
Subject(s) - leucine rich repeat , biology , structural plasticity , leucine , synaptic plasticity , membrane protein , cytoplasm , neuroscience , microbiology and biotechnology , genetics , amino acid , gene , membrane , receptor
Leucine‐rich repeats (LRRs) are 20–29‐aa motifs that mediate protein–protein interactions and are present in a variety of membrane and cytoplasmic proteins. Many LRR proteins with neuronal functions have been reported. Here, we summarize an emerging group of synaptic LRR proteins, which includes densin‐180, Erbin, NGL, SALM, and LGI1. These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses. © 2007 Wiley‐Liss, Inc.