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Modulation of normal and altered hippocampal excitability states by septal networks
Author(s) -
Colom Luis V.,
GarridoSanabria Emilio
Publication year - 2007
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.21276
Subject(s) - hippocampal formation , neuroscience , basal forebrain , mechanism (biology) , cognition , forebrain , psychology , medicine , physics , central nervous system , quantum mechanics
The septal region of the basal forebrain plays a dual role: 1) It modulates hippocampal excitability, facilitating synaptic plasticity within hippocampal circuits. Through this mechanism, the septum facilitates diverse cognitive processes that involve hippocampal circuits. 2) Additionally, the septum maintains the hippocampal networks working within normal ranges, decreasing the probability of abnormal excitability states. Through this second mechanism, the septum prevents the occurrence of epileptic discharges. Thus, septal alterations may lead to both decreased cognitive functions and epilepsy, as observed in elderly patients affected with Alzheimer's disease. © 2007 Wiley‐Liss, Inc.