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Deafness‐related decreases in glycine‐immunoreactive labeling in the rat cochlear nucleus
Author(s) -
Asako Mikiya,
Holt Avril G.,
Griffith Ronald D.,
Buras Eric D.,
Altschuler Richard A.
Publication year - 2005
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.20542
Subject(s) - glycine , dorsal cochlear nucleus , cochlear nucleus , glycine receptor , nucleus , hepatic stellate cell , biology , inhibitory postsynaptic potential , chemistry , microbiology and biotechnology , anatomy , neuroscience , endocrinology , amino acid , biochemistry
There is increasing evidence of activity‐related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine‐immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine‐immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine‐immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. © 2005 Wiley‐Liss, Inc.