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Characterization of retinoic acid neuromodulation in the carp retina
Author(s) -
Dirks Petra,
Tieding Silke,
Schneider Ilka,
Mey Jörg,
Weiler Reto
Publication year - 2004
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.20253
Subject(s) - retina , retinaldehyde , neuroscience , retinal , biology , microbiology and biotechnology , efferent , chemistry , biochemistry , rhodopsin , afferent
Visual sensation in vertebrates starts with the isomerization of 11‐ cis retinaldehyde into all‐ trans retinaldehyde. Aldehyde dehydrogenases, present in the pigment epithelium and some retinal cells, convert all‐ trans retinaldehyde into all‐ trans retinoic acid (at‐RA). Evidence in the retina and the hippocampus has accumulated, showing that at‐RA, besides being a morphogenetic factor, also acts as a neuromodulator. In mature retina, at‐RA affects visual processing by acting on gap junctional conductances and the synaptic transfer between photoreceptors and horizontal cells. We present evidence supporting a neuromodulatory role of at‐RA in the carp retina. High performance liquid chromatography (HPLC) measurements and an RA bioassay indicate a light dependency of at‐RA formation, which can explain the observed effects of at‐RA on spinule formation at horizontal cell dendrites in this retina. Furthermore, inhibiting endogenous metabolism and catabolism of at‐RA affects formation and persistence of spinules in a way, supporting a direct involvement of at‐RA in this light‐dependent mechanism of synaptic plasticity. The action of at‐RA, however, seems independent of the dopaminergic system, known for its light‐signaling role in the retina, because at‐RA effects on spinule formation persisted in retina depleted of dopaminergic neurons or in the presence of haloperidol. Together, these data indicate that at‐RA acts effectively as a direct neuromodulator in carp retina, transmitting information about ambient light conditions to the neuronal retina. © 2004 Wiley‐Liss, Inc.