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Neurogenesis in the subventricular zone following transcranial magnetic field stimulation and nigrostriatal lesions
Author(s) -
AriasCarrión O.,
VerdugoDíaz L.,
FeriaVelasco A.,
MillánAldaco D.,
Gutiérrez A.A.,
HernándezCruz A.,
DruckerColín R.
Publication year - 2004
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.20235
Subject(s) - neurogenesis , subventricular zone , subgranular zone , neuroscience , neun , dentate gyrus , biology , lesion , doublecortin , rostral migratory stream , hippocampus , hippocampal formation , neural stem cell , subependymal zone , stem cell , microbiology and biotechnology , pathology , medicine , immunology , immunohistochemistry
Neurogenesis continues at least in two regions of the mammalian adult brain, the subventricular zone (SVZ) and the subgranular zone in hippocampal dentate gyrus. Neurogenesis in these regions is subjected to physiological regulation and can be modified by pharmacological and pathological events. Here we report the induction of neurogenesis in the SVZ and the differentiation after nigrostriatal pathway lesion along with transcranial magnetic field stimulation (TMFS) in adult rats. Significant numbers of proliferating cells demonstrated by bromodeoxyuridine‐positive reaction colocalized with the neuronal marker NeuN were detected bilaterally in the SVZ, and several of these cells also expressed tyrosine hydroxylase. Transplanted chromaffin cells into lesioned animals also induced bilateral appearance of subependymal cells. These results show for the first time that unilateral lesion, transplant, and/or TMFS induce neurogenesis in the SVZ of rats and also that TMFS prevents the motor alterations induced by the lesion. © 2004 Wiley‐Liss, Inc.