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Specificity of regulatory CD4 + CD25 + T cells for self‐T cell receptor determinants
Author(s) -
Buenafe Abigail C.,
Tsaknaridis Laura,
Spencer Leslie,
Hicks Kevin S.,
McMahan Rachel H.,
Watson Lisa,
Culbertson Nicole E.,
Latocha Dorian,
Wegmann Keith,
Finn Tom,
Bartholomew Richard,
Burrows Gregory G.,
Whitham Ruth,
Bourdette Dennis N.,
Jones Richard E.,
Offner Halina,
Chou Yuan K.,
Vandenbark Arthur A.
Publication year - 2004
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.20066
Subject(s) - t cell receptor , il 2 receptor , biology , t cell , antigen , microbiology and biotechnology , population , genetics , immune system , medicine , environmental health
Although the phenotypic and regulatory properties of the CD4 + CD25 + T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4 + CD25 + Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoire as well as that of a clonotypic nongermline‐encoded CDR3β sequence present in a recombinant soluble T cell receptor (TCR) protein. Regulatory activity was demonstrated in T cell lines responsive to TCR but not in T cell lines responsive to control antigens. Inhibitory activity of TCR‐reactive T cells required cell–cell contact and involved CTLA‐4, GITR, IL‐10, and IL‐17. Thus, the T–T regulatory network includes Treg cells with specificity directed toward self‐TCR determinants. © 2004 Wiley‐Liss, Inc.