Role of calcium and kinases on the neurotrophic effect induced by γ‐aminobutyric acid | Zendy

Fiszman Mónica L. | Zendy; Schousboe Arne | Zendy

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Role of calcium and kinases on the neurotrophic effect induced by γ‐aminobutyric acid

Author(s) -

Fiszman Mónica L.,

Schousboe Arne

Publication year - 2004

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.20062

Subject(s) - neurotrophin , neuroscience , neurotrophic factors , aminobutyric acid , depolarization , mediator , nervous system , calcium , biology , intracellular , gamma aminobutyric acid , calcium in biology , gabaergic , chemistry , microbiology and biotechnology , endocrinology , biochemistry , receptor , inhibitory postsynaptic potential , organic chemistry

An increasing body of evidence supports a trophic action of γ‐aminobutyric acid (GABA) during nervous system development. The purported mediator of these trophic effects is a depolarizing response triggered by GABA, which elicits a calcium influx in immature CNS cells. This Mini‐Review focuses on the neurotrophic role of neural activity and GABA and some of the most common intracellular cascades activated by depolarization and trophic factors. Several biological effects induced by GABA in the developing nervous system are reviewed, with particular emphasis on what is known about calcium‐dependent neurotrophic effects induced by GABA and its intracellular mechanisms. © 2004 Wiley‐Liss, Inc.

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