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Multifaceted dialogue between graft and host in neurotransplantation
Author(s) -
Ourednik Vaclav,
Ourednik Jitka
Publication year - 2004
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.20037
Subject(s) - regeneration (biology) , host (biology) , neuroscience , biology , host factors , ecology , microbiology and biotechnology , immunology , virus
Current restorative neurotransplantation research focuses mainly on the potential of the neural graft to replace damaged or missing cell populations and to deliver needed gene products in the form of transgenes. Because of this graft‐oriented bias of the procedure, possible dormant regenerative capabilities within the host have been largely underestimated and dismissed as insignificant. This review discusses existing evidence that neural grafts can have stimulating effects on host‐intrinsic plasticity that can help regeneration of the mammalian central nervous system. If confirmed, the synergistic interaction between graft and host might substantially enhance our therapeutic possibilities. © 2004 Wiley‐Liss, Inc.