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BDNF dependence in neuroblastoma
Author(s) -
Feng Xuan,
Jiang Hong,
Baik John C.,
Edgar Cory,
Eide Fernette F.
Publication year - 2001
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.1086
Subject(s) - tropomyosin receptor kinase b , neuroblastoma , neurotrophic factors , neural crest , autocrine signalling , retinoic acid , neurotrophin , cancer research , brain derived neurotrophic factor , biology , tropomyosin receptor kinase a , neuroscience , sh sy5y , nerve growth factor , stimulation , medicine , endocrinology , cell culture , microbiology and biotechnology , receptor , genetics , embryo
Neuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied. Here we show that brief treatment with retinoic acid (RA) rendered the human neuroblastoma lines SY5Y, NGP, SMS‐KCNR, and SK‐N‐SH dependent on brain‐derived neurotrophic factor (BDNF) for survival. The BDNF‐ and trkB‐expressing line SMS‐KCN was dependent on an autocrine BDNF/trkB survival without exposure to RA. We conclude that the BDNF/trkB pathway plays an important role in neuroblastoma survival and speculate on a possible role in tumor pathogenesis. J. Neurosci. Res. 64:355–363, 2001. © 2001 Wiley‐Liss, Inc.