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Estrogen and cognition: Applying preclinical findings to clinical perspectives
Author(s) -
Gibbs Robert B.,
Gabor Rachel
Publication year - 2003
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10811
Subject(s) - cognition , hormone replacement therapy (female to male) , estrogen , regimen , medicine , meaning (existential) , hormone therapy , estrogen replacement therapy , psychology , cognitive decline , psychotherapist , clinical psychology , neuroscience , dementia , breast cancer , cancer , disease , testosterone (patch)
The effects of hormone replacement therapy on brain aging and cognition are an important public health issue, which, despite much research and debate, has not yet been resolved. In this Mini‐Review, we describe how much of the clinical literature takes on new meaning when interpreted in light of recent preclinical data. We predict, based on these data, that hormone replacement therapy will in fact provide substantial benefit with respect to age‐related cognitive decline, provided that therapy is administered in an appropriate regimen and is initiated within a window of time following the loss of ovarian function. The application of these data to recent clinical findings is discussed. © 2003 Wiley‐Liss, Inc.