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Transcriptional regulation through glutamate receptors: Involvement of tyrosine kinases
Author(s) -
LópezBayghen Esther,
Aguirre Adán,
Ortega Arturo
Publication year - 2003
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10807
Subject(s) - receptor tyrosine kinase , glutamate receptor , kainate receptor , microbiology and biotechnology , biology , metabotropic glutamate receptor 6 , metabotropic glutamate receptor 7 , tyrosine phosphorylation , long term depression , metabotropic glutamate receptor 5 , kinase , chemistry , receptor , biochemistry , metabotropic glutamate receptor , ampa receptor
Glutamate receptors play a key role in neuronal plasticity, learning and memory, and in several neuropathologies. Short‐term and long‐term changes in synaptic efficacy are triggered by glutamate. Although an enhanced glutamate‐dependent tyrosine phosphorylation has been described in several systems, its role in membrane‐to‐nuclei signaling is unclear. Taking advantage of the fact that the gene encoding the chick kainate‐binding protein undergoes a glutamate‐dependent transcriptional regulation via an activator protein‐1 (AP‐1) site, we evaluated the involvement of tyrosine kinases in this process. We describe here the participation of receptor and non‐receptor tyrosine kinases in the signaling cascade triggered by glutamate. Our results suggest that in Bergmann glia cells, glutamate receptors transactivate receptor tyrosine kinases, favoring the idea of a complex network of signals activated by this excitatory neurotransmitter that results in regulation of gene expression. © 2003 Wiley‐Liss, Inc.