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Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse
Author(s) -
Ivanova Anna,
Nakahira Eiko,
Kagawa Tetsushi,
Oba Akio,
Wada Tamaki,
Takebayashi Hirohide,
Spassky Nathalie,
Levine Joel,
Zalc Bernard,
Ikenaka Kazuhiro
Publication year - 2003
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10717
Subject(s) - subventricular zone , forebrain , neuroscience , cortex (anatomy) , biology , ganglionic eminence , olig2 , cerebral cortex , oligodendrocyte , corticogenesis , anatomy , progenitor cell , stem cell , myelin , microbiology and biotechnology , central nervous system , cerebrum
The existing view is that cortical oligodendrocytes (OLs) in rodents are born from the cortical subventricular zone (SVZ) after birth, but recent data suggest that many forebrain oligodendrocyte progenitor cells (OPCs) are specified much earlier (between E9.5 and E13.5 in the mouse) in the ventricular zone of the ventral forebrain under the control of sonic hedgehog (Shh) and migrate into the cortex afterward. We examined expression of specific early OL markers ( PDGFR α, PLP / DM20 , Olig2 , and NG2) in the developing forebrain to clarify this issue. We propose that OPCs colonize the developing cortex in two temporally distinct waves. The gray matter is at least partially populated by a first wave of OPCs that arises in the medial ganglionic eminence and the entopeduncular area and spreads into the cortex via the developing cortical plate. The cerebral cortex benefits from the second wave of OPCs coming from residential SVZ. In the second wave, there might be two different types of precursor cells: PLP / DM20 + cells populating only inner layers and PDGFR α + cells, which might eventually myelinate the outer regions as well. © 2003 Wiley‐Liss, Inc.