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Glial transporters for glutamate, glycine, and GABA III. Glycine transporters
Author(s) -
Gadea Ana,
María LópezColomé Ana
Publication year - 2001
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.1069
Subject(s) - glycine , glycine receptor , neurotransmission , glutamate receptor , inhibitory postsynaptic potential , transporter , nmda receptor , biochemistry , microbiology and biotechnology , synaptic cleft , biology , amino acid , excitatory postsynaptic potential , receptor , chemistry , neuroscience , gene
Glial cells possess transport systems for the three major amino acid neurotransmitters glutamate, γ‐aminobutyric acid (GABA) and glycine, involved in the arrest of neurotransmission mediated by these compounds. Two glycine transporters have been cloned: GLYT1, mainly expressed by glial cells and shown to colocalize with NMDA receptors, and GLYT2, exclusively expressed by neurons and colocalized with the inhibitory glycine receptors. The way in which the regulation of extracellular glycine concentration by glial glycine transporters affects physiological and pathological conditions is discussed. The presence, differential pharmacology and specific regulation of glycine transporters in glial cells strongly support an important role for glia in the modulation of both, excitatory and inhibitory neurotransmission. J. Neurosci. Res. 64:218–222, 2001. © 2001 Wiley‐Liss, Inc.