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Increased neurogenesis after experimental Streptococcus pneumoniae meningitis
Author(s) -
Gerber Joachim,
Böttcher Tobias,
Bering Judith,
Bunkowski Stephanie,
Brück Wolfgang,
Kuhnt Ulrich,
Nau Roland
Publication year - 2003
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10682
Subject(s) - dentate gyrus , bromodeoxyuridine , neurogenesis , subgranular zone , hippocampal formation , biology , meningitis , progenitor cell , neural stem cell , streptococcus pneumoniae , immunology , neuroscience , microbiology and biotechnology , immunohistochemistry , pathology , medicine , stem cell , subventricular zone , psychiatry , antibiotics
Neuronal damage in the hippocampal formation is a common feature in animal models of bacterial meningitis and human disease. In mouse and rabbit models of Streptococcus pneumoniae meningitis, proliferation of neural progenitor cells quantified by bromodeoxyuridine (BrdU) incorporation was enhanced in the subgranular layer of the dentate gyrus. In mice, the density of BrdU‐labeled cells was maximal on Day 2 after infection. Approximately 60% of the cells labeled by BrdU between Days 7 and 10 after infection that remained present 28 days later had migrated into deeper layers of the dentate gyrus and differentiated into neurons, as evidenced by immunohistochemical staining for TUC‐4, MAP‐2 and beta‐tubulin. This suggests that endogenous repair mechanisms may limit consequences of neuronal destruction after meningitis. © 2003 Wiley‐Liss, Inc.