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Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor‐2
Author(s) -
Rolf Bettina,
Lang Doris,
Hillenbrand Rainer,
Richter Melanie,
Schachner Melitta,
Bartsch Udo
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10533
Subject(s) - neurite , optic nerve , fibroblast growth factor , microbiology and biotechnology , biology , nerve growth factor , retina , glial scar , in vitro , central nervous system , astrocyte , neuroscience , genetics , receptor
The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up‐regulate expression of CHL1 in response to an intraorbital crush of the adult mouse optic nerve. We also demonstrate that a single intravitreal application of fibroblast growth factor‐2 (FGF‐2) increases expression of CHL1 in retinal astrocytes and Müller cells. Elevated expression of CHL1 by glial cells in injured optic nerves and astrocytes and Müller cells in FGF‐2‐treated retinas suggests a role of the protein in the lesioned central nervous system. Results also suggest that trophic factors might exert part of their biological function by modifying expression of cell recognition molecules. © 2002 Wiley‐Liss, Inc.