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Effects of peroxisome proliferator‐activated receptor‐γ agonists on central nervous system inflammation
Author(s) -
Kielian Tammy,
Drew Paul D.
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10501
Subject(s) - experimental autoimmune encephalomyelitis , peroxisome proliferator activated receptor , multiple sclerosis , inflammation , ppar agonist , microglia , receptor , proinflammatory cytokine , immune system , peroxisome proliferator activated receptor gamma , agonist , pharmacology , biology , endocrinology , medicine , immunology
Peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) plays a critical role in glucose and lipid metabolism. More recently, PPAR‐γ ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR‐γ agonists have been demonstrated to have similar effects on microglia. PPAR‐γ agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini‐Review summarizes the effects of PPAR‐γ agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS. © 2002 Wiley‐Liss, Inc.