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Role of mitochondrial dysfunction in Alzheimer's disease
Author(s) -
Castellani Rudy,
Hirai Keisuke,
Aliev Gjumrakch,
Drew Kelly L.,
Nunomura Akihiko,
Takeda Atsushi,
Cash Adam D.,
Obrenovich Mark E.,
Perry George,
Smith Mark A.
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10389
Subject(s) - disease , pathological , neuroscience , alzheimer's disease , mitochondrion , medicine , mitochondrial disease , mitochondrial dna , psychology , biology , pathology , genetics , gene
Abstract Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease. © 2002 Wiley‐Liss, Inc.