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Dual role for p75 NTR signaling in survival and cell death: Can intracellular mediators provide an explanation?
Author(s) -
Mamidipudi Vidya,
Wooten Marie W.
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10244
Subject(s) - tropomyosin receptor kinase a , microbiology and biotechnology , intracellular , kinase , second messenger system , low affinity nerve growth factor receptor , signal transduction , biology , protein kinase c , protein kinase a , nerve growth factor , receptor , biochemistry
Abstract Several recent reports support a dual role of p75 NTR in cell death, as well as survival, depending on the physiological or developmental stage of the cells. Coexpression of the TrkA receptor with p75 NTR further enhances the complexity of nerve growth factor (NGF) signaling. Recent identification of serine/threonine kinases that interact with the p75 NTR provides an explanation for the lack of an apparent kinase domain needed for signaling. In this report, we review the possible roles of the intracellular proteins that directly interact with the p75 NTR , atypical protein kinase C (PKC) binding protein, p62 and second messengers in the functional antagonism exhibited by TrkA and p75 NTR with an emphasis on the nuclear factor‐kappa B activation pathway. © 2002 Wiley‐Liss, Inc.