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Nogos and the Nogo‐66 receptor: Factors inhibiting CNS neuron regeneration
Author(s) -
Ng Cherry Ee Lin,
Tang Bor Luen
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10134
Subject(s) - neurite , biology , microbiology and biotechnology , transmembrane protein , regeneration (biology) , extracellular , transmembrane domain , receptor , leucine rich repeat , biochemistry , kinase , in vitro
The recently cloned gene Nogo, whose alternative splice products correspond to the antigenic target of the central nervous system (CNS) regeneration enhancing monoclonal antibody IN‐1, codes for membrane proteins enriched in brain, particularly in oligodendrocytes. The 66‐amino acid extracellular domain of Nogo (Nogo‐66) interacts with a high‐affinity receptor (NgR), a glycosylphosphatidylinositol (GPI)‐linked protein with multiple leucine‐rich repeats. The amino terminal cytoplasmic domain of Nogo appears to have a general cellular growth inhibitory effect. Nogo‐66, on the other hand, specifically retards neurite outgrowth and induces growth cone collapse, possibly through its interaction with NgR and as yet unidentified transmembrane coreceptors. Recent results also suggest that Nogo expression may induce apoptosis in tumor cells. Together, these proteins provide new molecular handles for the design of therapeutic interventions for CNS injuries and neurodegenerative diseases, as well as possible leads to anticancer strategies. © 2002 Wiley‐Liss, Inc.